Nephros believes that, with Dual Stage technology and 0.005 micron filtration, we have developed the safest and the only water filter on the market that can effectively deliver point of use biocontaminant-free water for drinking and bathing. Bacteria sizes range from 0.5 to 5 microns; viruses and other bio-toxins are considerably smaller, although the vast majority of known biological toxins are .005 microns in size or larger.
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1. Blood enters the outer fiber bundle.

2. Substitution fluid dilutes blood; blood flow reverses 180º   to enter core fibers.

3. Blood from core fiber bundle exits the OLpūr™MD 190 filter.
NEPHROS gives you MORE ß2-microglobulin clearance!
MORE ß2-microglobulin clearance Is BETTER!
Potential Benefits of Hemodiafiltration:
  Improved survival (1,2,3)
Reduction in ß2-M related amyloidosis
Improved anemia profile (5,6,7)
Reduced medication requirements (6,7)
Improved blood pressure control (7)
Increased phosphorus removal (8)
 
 
  1. Locatelli F, Marcelli D, Conte F, Limido A, Malberti F, Spotti D Comparison of mortality in ESRD patients on convective and diffusive extracorporeal treatments. The Registro Lombardo Dialisi E Trapianto. Kidney Int. 1999 Jan;55(1):286-93
  2. Held PJ, Port FK, Wolfe RA, Stannard DC, Carroll CE, Daugirdas JT, Bloembergen WE, Greer JW, Hakim RM The dose of hemodialysis and patient mortality. Kidney Int. 1996 Aug;50(2):550-6
  3. Leypoldt JK, Cheung AK, Carroll CE, Stannard DC, Pereira BJ, Agodoa LY, Port FK Effect of dialysis membranes and middle molecule removal on chronic hemodialysis patient survival. Am J Kidney Dis. 1999 Feb;33(2):349-55
  4. Lin CL, Huang CC, Yu CC, Wu CH, Chang CT, Hsu HH, Hsu PY, Yang CW Improved iron utilization and reduced erythropoietin resistance by on-line hemodiafiltration. Blood Purif. 2002;20(4):349-56
  5. Bonforte G, Grillo P, Zerbi S, Surian M Improvement of anemia in hemodialysis patients treated by hemodiafiltration with high-volume on-line-prepared substitution fluid. Blood Purif. 2002;20(4):357-63
  6. Canaud B, NGuyen QV, Polito C, Stec F, Mion C Hemodiafiltration with on-line production of bicarbonate infusate. A new standard for high-efficiency, low-cost dialysis in elderly and uncompliant patients. Contrib Nephrol. 1989;74:91-100
  7. Maduell F, del Pozo C, Garcia H, Sanchez L, Hdez-Jaras J, Albero MD, Calvo C, Torregrosa I, Navarro V Change from conventional haemodiafiltration to on-line haemodiafiltration. Nephrol Dial Transplant. 1999 May;14(5):1202-7
  8. Minutolo R, Bellizzi V, Cioffi M, Iodice C, Giannattasio P, Andreucci M, Terracciano V, Di Iorio BR, Conte G, De Nicola L Postdialytic rebound of serum phosphorus: pathogenetic and clinical insights. J Am Soc Nephrol. 2002 Apr;13(4):1046-54